Glutathione Protects Against Neurotoxicity
The evidence just continues to mount in favor of the MaxGXL revolution. Checkout this excerp from a major research study on the effects of glutatione on neurotoxicity from chemotherapy treatment. We shouldn’t simply desire this product.. We should demand it!
Aug. 23, 2002 — Glutathione may protect against the neurotoxicity of oxaliplatin, a relatively new chemotherapeutic used in the treatment of colorectal and other cancers, according to the results of a randomized controlled trial reported in the Aug. 15 issue of the Journal of Clinical Oncology. Even better, this inexpensive drug does not adversely affect the efficacy of oxaliplatin.
“An optimal strategy for reducing the neurotoxicity associated with oxaliplatin may be the use of agents such as glutathione, which may be able to prevent the initial accumulation of platinum adducts in dorsal root ganglia,” write Stefano Cascinu, MD, and colleagues from the Universitaria di Parma in Italy. “The lack of toxicity and interference with oxaliplatin activity, as well as its low economic cost, makes glutathione an ideal new drug for the prevention of oxaliplatin-induced neuropathy in colorectal cancer patients.”
You can read the full article by Laurie Barclay, MD right HERE
Breaking News: Glutathione Synthetase Deficiency
For several years I have been zeroing in on inflammatory issues that cause heart arrhythmias. My research led me to the study of mercury in fish and fish oils, and to dietary items that have the potential to lead to systemic inflammation. My own heart issues started in 2002. By 2008 I had nailed enough of the risk factors to completely stop my own atrial fibrilation episodes. I even went as far as to create a website to address the issue.
Continued studies led me to research the powerfully antioxidant properties of Kangen Water. Eventually I discovered my own source (Hunzana – a proprietary and patented formulation) for a water concentrate that was both low in oxidative reduction potential (ORP) and high in pH (13.0). In addition Hunzana has a low surface tension making it become what I think is the world’s most powerful nutritive enabler of it’s kind. The water’s properties allow it to treat ordinary tap water (or bottled water) and to make it into high alkaline (pH 9.0) – low ORP (-20) water that enhances the bioavailability of everything you eat or drink. Imagine the implications here!
I find it a miracle of coincidence that only two weeks ago I met my friend Dal Carter, who introduced me to MaxGXL. Thank God I listened to him! Evidently, both the efficacy of Max and my journey to discover wellness are intricately tied. I believe in a higher power and that everything happens for a reason. When Dal sent me this article tonight, I was astounded by the ramifications of this study by Drs. Adams and Wasserstein.
We are clearly on the cusp of something so great that non of us will appreciate just how so for many years to come. Please read the briefing below and then visit the WebMD site noted at the bottom of this article.
Nick.
Background
Glutathione synthetase (GS) deficiency, first described in 1970, is a rare inborn error of glutathione metabolism characterized by severe metabolic acidosis, hemolytic anemia, and neurological problems.23 Biochemical findings include massive excretion of 5-oxoproline in the urine. In mild glutathione synthetase deficiency, which is characterized by hemolytic anemia, enzyme deficiency primarily occurs in erythrocytes.
Pathophysiology
Glutathione is involved in several important biologic functions, including membrane transport, detoxification of xenobiotics, and protection of cells from free radicals. Glutathione is produced from the amino acids cysteine, glycine, and glutamine via the consecutive actions of gamma-glutamylcysteine synthetase and glutathione synthetase. It is also widely used by RBCs, which are vulnerable to oxidative damage caused by peroxides. Reduced glutathione is required as an antioxidant in these cases.
Multiple mutations that cause glutathione synthetase deficiency have been described in the glutathione synthetase gene, GSS. The erythrocyte variant has been linked to a homozygous missense mutation that causes enzyme instability; thus, enzyme deficiency is most significant in erythrocytes and manifests as hemolytic anemia. Thirteen different missense mutations in GSS have been identified in individuals with severe glutathione synthetase deficiency.1 The mutations were found in 9 unrelated patients from different geographic areas. Two of these mutations were in individuals who were found to have CNS involvement. In all cases, residual enzyme activity was noted, indicating that a complete loss of enzyme function is probably lethal.
History
The phenotypic manifestations that have been described in association with glutathione synthetase (GS) deficiency include hemolytic anemia, which occurs in mild glutathione synthetase deficiency, and 5-oxoprolinuria (pyroglutamicaciduria) and variable degrees of secondary neurological involvement (occurring in systemic glutathione synthetase deficiency). As stated in Mortality/Morbidity, authors have suggested glutathione synthetase deficiency be described as mild, moderate, or severe. These categories represent a continuum of disease severity that depends on the degree of enzyme function; therefore, patients can have manifestations anywhere along the continuum of mild to severe glutathione synthetase deficiency.
- The severe phenotypic manifestation, 5-oxoprolinuria (pyroglutamicaciduria), resulting from systemic glutathione synthetase deficiency, is an autosomal recessive disorder. It is characterized by very large peaks of 5-oxoproline on urine organic acid analysis findings, metabolic acidosis, hemolytic anemia, and eventual CNS damage. Because of deficient enzyme activity, a decreased quantity of glutathione results, which likely causes promoter activation of the GSS gene. The large amounts of gamma-glutamylcysteine synthetase that are produced increase the pool of gamma-glutamylcysteine, which is then converted to 5-oxproline because of the inability of the defective GSS gene to produce glutathione.
- In moderate glutathione synthetase deficiency, neonatal acidosis and hemolytic anemia are present, but neurological involvement is not. The prognosis for the moderate form is intermediate.
- In mild glutathione synthetase deficiency, hemolytic anemia is the primary finding with apparently no effects outside of erythrocytes. Individuals with this form do well clinically.
Medical Care
Treatment of individuals who have been diagnosed with glutathione synthetase (GS) deficiency involves providing supplements to correct the metabolic acidosis and supplying antioxidants such as vitamin E and vitamin C. A combination of sodium citrate and citric acid (Bicitra) may be used as an oral medication and can maintain plasma bicarbonate levels within the reference range. Alternatively, bicarbonate may be used; however, very large doses may be needed.
Alkalinizing agents
Sodium bicarbonate is used as a gastric, systemic, and urinary alkalinizer and has been used in the treatment of acidosis resulting from metabolic and respiratory causes, including diabetic coma, diarrhea, kidney disturbances, and shock. Sodium bicarbonate also increases renal clearance of acidic drugs. Citric acid mixtures may also be used. With normal hepatic function, 1 mEq of citrate is converted to 1 mEq of bicarbonate.
Vitamins and antioxidants
These are organic substances required by the body in small amounts for various metabolic processes. Vitamins may be synthesized in small or insufficient amounts in the body or not synthesized at all, thus requiring supplementation. They are used clinically for the prevention and treatment of specific vitamin deficiency states.
Prognosis
- In the systemic form, chronic metabolic acidosis must be treated, but long-term prognosis is guarded. The lack of glutathione in erythrocytes alone is apparently tolerable, as has been noted with the peripheral form of this condition; however, in severe glutathione synthetase, a progressive loss of function occurs, leading to severe mental retardation, ataxia, and seizure disorders.
- The oldest reported survivor of severe glutathione synthetase was aged 24 years and had experienced significant neurological deterioration over the previous few years. Older children with mild and moderate forms who are doing well have been reported.
The entire article should be studied HERE
Authors:
Darius J Adams, MD, Assistant Professor, Department of Pediatrics, Section of Genetics and Metabolism, Albany Medical Center
Melissa P Wasserstein, MD, Associate Professor, Departments of Genetics and Genomic Sciences and Pediatrics, Mount Sinai School of Medicine
Heart Palpitations Linked to Diet…
After 7 years chasing down data from palpitation sufferers, one trend is becoming clear. There is no doubt in my mind that many forms of heart palpitation can be traced directly to gastro-intestinal distress. I recently read a book by Dr. Hiromi Shinya called “The Enzyme Factor”. Dr. Shinya confirms my belief that North American Diets are affecting our systems in ways that most doctors do not understand.
One thing you must remember is that doctors study from BOOKS…and are taught by old professors … who studied from OLD BOOKS a very long time ago. When you trot off to your doctor complaining about palpitations, he/she will run you through the standard battery of tests. Once you’ve had your holter test, your echo cardiogram, your ultra sound, your blood work and your treadmill test… the doctor will tell you that you are stressed and that much of it is psychological. This is, of course, hogwash. You and I both know that. You are hear because you didn’t believe what your doctor told you. You had a sneaky feeling that there was something else causing your palpitations. And you were right!
Symptoms of Palpitation and Panic Attacks
Symptoms of Panic Attacks
When someone is suffering from a panic attack, the underlying feeling is that there is an extreme anxiety response happening. Many people aren’t even aware of what triggered the response. The onset of is sudden… and the symptoms are usually very frightening to the recipient. Some panic attack sufferers believe that they are having a heart attack, or that the feelings they are experiencing will lead them to a heart attack. Most people, at this moment begin to contemplate death… and the feeling is quite unwelcome! While people do not typically die from panic attacks, the symptoms are devastating to the psyche… since you get live and experience it all over again!
Palpitations, Panic Attacks & Anxiety Disorder Information
Palpitations, Panic Attacks & Anxiety Disorder Information
According to health care professionals, panic attacks and related anxiety related disorders are an considered to manifest from an irrational fear – that often begins in the subconscious mind. The result is often an increased or arrhythmic heart rate, an increased breathing rate that is sometimes accompanied by chills or sweating. It should be noted here that while heart arrhythmias are often caused by panic attacks or anxiety disorders, there are other causes of arrhythmia. These are related to physical and nutritional risk factors and will be discussed in a future article.
Heart Palpitations and Panic Attacks Help
Palpitations and Panic Attacks Help
Panic attack sufferers are thoroughly familiar with the shortness of breath, pounding heart, dizziness, and stomach issues that are associated with their anxiety. They can even experience a tightness in the neck… as though they had just been running. What an outsider might not understand is that panic attacks are a very private, and sometimes embarrassing thing. The person who is suffering from them is typically worried about an irrational fear, first off, and then by the prospects of death! In the depths of their soul they might know the fear is irrational but, once they are into it.. .there is no turning back. It has to run its course. Sufferers typically feel shame about how far their fear has gone and how much it has affected their life. They can even display levity by laughing in the midst of the attack. Consciously they know the fear is irrational but they just can’t find the trigger to prevent it. Because of this, a lot of panic attack sufferers do not seek help. Those who do seek help can find it in a variety of ways.
Panic Attack Medication
Panic Attack Medication
We already know that panic attacks can be a debilitating affliction that causes the individual that is suffering from it great stress and discomfort. At some point one had to enter into a discussion about medication. And we all understand that this is a very controversial topic.
At the basal level, panic disorders can be treated through the use of medication. If you spend any time online researching this subject, you will quickly find that there are about as many opinions on this topic as there are people writing about it. At the risk of getting sued by some exuberantly defensive pharmaceutical representative, I am not going to name medications. I will refer to them generically.
I will say once again upfront… that I am very much against the use of pharmaceutical drugs to alter my body chemistry so that a symptom or affect can be masked or hidden from me. I am not fooled by the school that thinks just because you can feel it.. It must be gone!
Causes of Heart Palpitations and Panic Attacks
Causes of Heart Palpitations and Panic Attacks
This might be the 60 million dollar question. Everyone wants to know what causes their attacks. For each of us it is different. Suddenly we find ourselves experiencing feelings of intense fear and apprehension, accompanied by heart palpitations, shortness of breath, sweating, trembling plus probably several other symptoms. So many times I’ve heard it said by the patient that “I was feeling great! I was just driving along and suddenly…” Clearly it is not fully understood what the cause of the panic attacks is but I’ve managed to cull out a number of risk factors in the 7 years that I have been researching this subject. These factors include a combination of things that are both biological and environmental in scope.
Anxiety Disorders In Children
Anxiety Disorders in Children
Who could argue that most children will experience a typical fear or anxiety during their life time. There are simply a ton of things to be nervous about these days. It could be from taking a test or starting a new school or moving to a new town and meeting new friends. Even worrying about being accepted by existing friends is a stress for some children. In most cases, however, these fears don’t become irrational or develop into some sort of mania or panic disorder. There will always be some children, however, that show the early signs of a panic disorder for a multitude of other reasons.
Medication for Panic Attacks and Heart Palpitations
We already know that panic attacks can be a debilitating affliction that causes the individual that is suffering from it great stress and discomfort. At some point one had to enter into a discussion about medication. And we all understand that this is a very controversial topic.
At the basal level, panic disorders can be treated through the use of medication. If you spend any time online researching this subject, you will quickly find that there are about as many opinions on this topic as there are people writing about it. At the risk of getting sued by some exuberantly defensive pharmaceutical representative, I am not going to name medications. I will refer to them generically.
